脑外伤颅内感染患者脑脊液检查病原菌分布及耐药性分析.docVIP

精品论文 参考文献 脑外伤颅内感染患者脑脊液检查病原菌分布及耐药性分析 周攀 　　（泸州医学院附属医院检验科 四川泸州 646000） 　　【摘要】目的：分析因脑外伤颅内感染而检查脑脊液病原菌分布及其耐药性的特点，为临床治疗制定治疗方案。方法：随机在本院选择80例明确有颅内感染的患者，按照感染原因的区别将其分为外伤组和非外伤组，分别有32例和48例，分析两组患者脑脊液病原菌特点，采取相应的方法研究、分析、总结外伤组患者中各细菌种类和耐药性，为临床医生提供治疗依据。结果:经检查后发现，外伤组患者53.1%（17例）为革兰阴性菌，明显高于非外伤组的20.8%（10例），相比之下，外伤组患者的革兰阳性菌显著少于非外伤组，差异显著，具有统计学意义，Plt;0.05。外伤组患者脑脊液中病原菌的耐药菌主要是MRSA和MRCNS，对于高级抗生素如亚胺培南、万古霉素等均不存在耐药菌。结论：脑外伤颅内感染患者脑脊液病原菌的种类与非外伤导致的颅内感染不同，外伤导致的颅内感染多以革兰阴性菌为主，耐药菌仍然是不可忽视的问题，由于病原菌的不同，耐药性也存在一定差异，因此在选择抗生素、制定治疗计划方面也会有所差异，鉴定颅内感染致病因素的区别有助于临床医生制定相应治疗方案，更加合理的应用抗生素。 　　【关键词】脑外伤；颅内感染；脑脊液；耐药性 　　【中图分类号】R446 【文献标识码】A 【文章编号】1007-8231（2015）21-0050-02 　　Distribution and drug resistance of pathogenic bacteria in cerebrospinal fluid of patients with intracranial infection Zhou Pan. 　　Department of Clinical Laboratory Inaffiliated Hospital of Luzhou Medical College ,SichuanLuzhou,646000,China 　　【Abstract】Objective To analyze the distribution and drug resistance of pathogenic bacteria in cerebrospinal fluid of patients with intracranial infection，and to develop a treatment plan for clinical treatment. Methods 80 patients with intracranial infection were randomly selected in our hospital.According to the difference of infection causes，patients were divided into 32cases and 48 cases respectively. Analyzed the characteristics of pathogenic bacteria in the two groups of patients with cerebrospinal fluid.Summarized the bacterial species and drug resistance of the patients in the trauma group，and provided the basis for clinical treatment. Results After examination，53.1% (17 cases) were found to be gram negative bacteria，which was significantly higher than that of non trauma group (10 cases)，compared with non trauma group，the positive bacteria were significantly less than those in non trauma group，the difference was statistically significant，Plt;0.05. MRSA and MRCNS were the main pathogenic bacteria in trauma group in cerebrospinal fluid of patients with drug-resistant b