功能性下颌偏斜对青春期大鼠髁突软骨VEGF的表达-第三军医大学学报.docVIP

功能性下颌偏斜青春期大鼠髁突软骨表达影响Effect of lateral functional shift of the mandible on the expression of VEGF of condylar cartilage in growing rats WANG Yao, XIA Xi, , DENG Feng, ZHANG Dingmin, WANG Huaqiao （The Affiliated Hospital of Stomatology, Chongqing Medical University. Chongqing Research Center for Oral Diseases and Biomedical Science.Chongqing. China 400015） Abstract: Objective To investigate the effect of lateral functional shift of the mandible on the express of vascular endothelial growth factor(VEGF) in condylar cartilage in growing rats.Methods Sixty four-week-old male Sprague-Dawley(SD) rats were randomly divided into experimental group (n=40) and control group (n=20). Each animal in experimental group received an appliance designed to produce lateral functional shift of the mandible. Ten and Five animals in the experimental and control groups were sacri?ced at four time points (7, 14, 21, and 28 days). Sagital and frontal sections were cut from left and right condyles, Immunostaining was performed to detect the expression level of VEGF. Results The expression of VEGF in the posterior region and central region of the right side of the experimental group were signi?cantly increased at 7、14、21、28days（P＜0.05）compared with the left side and control group.The expression of VEGF in lateral and posterior region of the left side of the experimental group were signi?cantly decreased at 7、14 、21and 28 days（P＜0.05）compared with the right side and the control group.Conclusion The lateral functional shift of the mandible can promote the expression of VEGF in the central and posterior region of the contralateral side, which promotes the transformation of cartilage to bone; While it decreased in the lateral and posterior region of the shift side may hinder the transformation of cartilage to bone, which suggesting that patients with mandibular lateral functional shift should be treated as early as possible. Key words: Lateral functional shift of the mandible; condylar cartilage;