骨炎去杖灵治疗慢性骨髓炎的实验研究.pdfVIP

提 要 目的：以中医学理论为指导, 根据益气养血、扶正祛邪、托毒生肌治则研制药物 骨炎去杖灵治疗慢性骨髓炎。运用现代科学手段，通过动物实验系统地观察治疗过程， 印证益气养血、扶正祛邪、托毒生肌治则的正确性，研究药物的作用机理，观察骨炎 去杖灵治疗慢性骨髓炎的疗效。方法：采用新西兰大白兔建立慢性骨髓炎动物模型， 随机分为4组：骨炎去杖灵组、肌注庆大霉素组、灌生理盐水组和肌注生理盐水组。 治疗5周，按设计分期进行一般情况观察、解剖学观察、放射学检查、组织学观察、 白细胞数量及血清溶菌酶含量测定。结果：骨炎去杖灵组与灌生理盐水组有非常显著 性差异；通过放射学检查、组织学观察及血清溶菌酶含量测定比较，骨炎去杖灵组明 显优于肌注庆大霉素组。 结论：骨炎去杖灵能提高机体免疫力、改善局部微循环、 促进骨髓炎骨质愈合，治疗慢性骨髓炎有良好疗效。 关键词 骨炎去杖灵；慢性骨髓炎；实验研究 Clinical study on Chronic Pyogenic Osteomyelitis by GuYanQuZhangLing Speciality :Orthopaedics and tranmstology of TCM Author:Wang Weiguo Tutor:Professor Xu Zhanwang Abstract Objactive:Under the guidance of Chinese Medicine theories, to base on replenishing qi and blood、strengthening healthy qi to eliminate pathogens、promoting pus discharge and tissue regeneration, we have developed this drug,which is a system of GuYanQuZhangLing to staff the curative effect of treating chronic pyogenic osteomyelitis. The use of modern scientific means, through animal experiments to observe the course of treatment system, confirms the correctness of replenishing qi and blood 、strengthening healthy qi to eliminate pathogens 、promoting pus discharge and tissue regeneration, mechanism of action of drugs,observe GuYanQuZhangLing GuYanQuZhangLing ’s efficacy of the treatment of Chronic Pyogenic Osteomyelitis.Methods: Establish animal model of chronic pyogenic osteomyelitis by New Zealand Rabbits,and randomly divided into four groups: GuYanQuZhangLing group﹑Muscle note gentamycin group ﹑Irrigation saline group and Muscle note saline group. Five weeks after treatment, according to design in stages observation, including: generally observed﹑anatomic observation﹑radiological examination﹑histologica