声门型喉癌组织c-met和EGFR蛋白表达及与局部-第三军医大学学报.DOCVIP

DOI：10.16016/j.1000-5404.201409109 c-met和EGFR蛋白表达与声门型喉磷癌术后复发的关系 蒋 梅1，肖 何1，张志敏2，陈 川1，毛必静1，张 辉1，李 建1，何 轩1，肖华亮3，杨镇洲1，王 东1，王 阁1（400042 重庆，第三军医大学大坪医院野战外科研究所：肿瘤中心1，病理科3；430070 武汉，广州军区武汉总医院肿瘤科2） [摘要目的探讨表皮生长因子受体EGFR)和肝细胞生长因子受体(mesenchymal-epithelial transition factor，c-Met)在声门型喉鳞癌中的表达及与术后复发的关系。方法66例声门型喉磷癌免疫组化法检测c-et及EGFR原发灶组织的表达情况，用H评分法对结果进行评估结果~270)和225 (0~270)。单变量Logistic分析表明，c-et或EGFR高表达患者的复发显著高于低表达患者OR=7.111, P0.001; OR=5.290, P=0.002)。分析表明c-et或EGFR的高表达均可作为喉癌术后复发的独立因素OR=5.909, P=0.002; OR=4.231, P=0.013)。ROC曲线联合c-Met和EGFR表达对术后复发具有效能。结论c-Met和EGFR表达均与声门型喉磷癌术后复发密切相关，。关键词声门型喉鳞癌；表皮生长因子受体；复发 Relationship between c-met and EGFR expression and postoperative recurrence in glottic laryngeal squamous cell carcinoma Jiang Mei1, Xiao He1, Zhang Zhimin2, Chen Chuan1, Mao Bijing1, Zhang Hui1, Li Jian1, He Xuan1, Xiao Hualiang3, Yang Zhenzhou1, Wang Dong1, Wang Ge1 (Cancer Center1, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China; Department of Oncology2, Wuhan General Hospital of Guangzhou Command, People’s Liberation Army, Wuhan, Hubei, 430070, China; Department of Pathology3, Daping Hospital, Third Military Medical University, Chongqing, 400042, China) [Abstract] Objective To explore the relationship between mesenchymal-epithelial transition factor (c-Met) and epidermal growth factor receptor (EGFR) expression and postoperative recurrence in glottic laryngeal squamous cell carcinoma (LSCC). Methods Immunohistochemistry accompanied with H scores was utilized to evaluate the expression of c-Met and EGFR in primary focus tissues of 66 patients with glottic LSCC, who were equally divided into a recurrence group and a non-recurrence group. If H scores were greater than the median values, the c-met and EGFR expression was defined as high expression, and conversely, low expression was defined. Results The median values of H-scores of c-Met and EGFR were 150 (0-270) and 225 (0-270), respectively. The univariate logistic r