(内分泌系统）骨质疏松用药PPT.pptVIP

Calcium—application Acute or chronic hypocalcemia; Tetany disease（手足抽搐）Rickets（佝偻病）; Osteomalacia（软骨病）, osteoporosis, parathyroid function impairment Magnesium poisoning counterpoison（镁中毒解救） (One key piece of advice is to take your calcium in several small doses throughout the day) . vitamin D3—application Osteoporosis Chronic renal failure For treatment and prevention of vitamin D deficiency Psoriasis （银屑癣） Osteoporosis is a disease of bone that commonly occurs in elderly people, and is characterized by the degeneration of bone superstructure, a decrease of bone strength , an increase of bone fragility and thus an increased risk of fracture. Drugs available for the prevention and treatment of osteoporosis are catalogued into three types in terms of their actions on affecting calcification and boneover. Key Concepts Antiresorptive agents, including bisphosphonates, calcitonin, estrogen and iprioavone which decrease the rate of bone loses through inhibiting the activity osteoclasts（破骨细胞）. Key Concepts The second group agents including fluoride,parathyroid hormone and androgens that promote bone formation by stimulating the activity of osteoblasts（成骨细胞） . . Please describe the classification and characteristic of osteoporosis drugs? ? Review questions * * * * * * * * * * * * * * * * * * * * Chapter Drugs used for the treatment of osteoporosis Department of pharmacology Liming zhou 2015.9 Contents Osteoporosis Antiresorptive drugs Bone-forming drugs Mineralization drugs Osteoporosis Osteoporosis is a disease characterized by low bone mass (bone thinning) that leads to fragile bones and an increased risk of fractures of the hip, spine, and wrist. Normal Osteoporosis Severe osteoporosis Common symptoms : Back pain Stooped posture Fractures Primary osteoporosis Secondary osteoporosis Idiopathic osteoporosis Postmenopausal osteoporosis Senile osteoporosis [ Osteoporosis—risk factors  Factors you cannot change Gender Age; Body size ;Ethni