(内分泌系统）Nuclear Medicine in Endocrine System.pptVIP

参考教材 Thank you! Email：huangrui1977@163.com Cell phone* * often called?overactive thyroid?and sometimes?hyperthyreosis, is a condition in which the?thyroid gland?produces?and secretes excessive amounts of is a condition in which your thyroid gland produces too much of the hormone thyroxine.?the free (not?protein?bound circulating in the blood[1])?thyroid hormones?-triiodothyronine?(T3) and/or?thyroxine?(T4)。Hyperthyroidism is one cause of?thyrotoxicosis—the?hypermetabolic?clinical?syndrome?which occurs when there are elevated?serum?levels of T3 and/or T4 * Graves disease?is the most common cause of hyperthyroidism * The therapeutic approaches to hyperthyroidism * There is considerable disparity of opinion regarding the first choice for patient with Graves?ˉ disease [3¨C5]. Each modality has its own indication, contraindication, advantage and disadvantage. available to assist the appropriate choice for each patient The cumulative experience on this therapy has confirmed its efficacy, safety and cost-effectiveness. At our institute, We have used iodine-131 for treatment of hyperthyroidism since 1959. Up to the end of 1998 , a total of 13 536 hyperthyroid patients were treated. Their principle action is to inhibit the organification of iodide and coupling of iodothyronines which in turn suppress the synthesis of thyroid horm radioiodine therapy is the most common therapy for Graves?ˉ disease. Hyperthyroidism has been treated with iodine-131 for over 70 years * The objective of radioiodine therapy is to destroy thyroid tissue sufficient for rendering euthyroid. The treatment goal is to administer enough radiation to achieve euthyroidism without causing hypothyroidism unless it is the intention of the physician to induce hypothyroid in some patients to avoid the risk of persistent hyperthyroidism. * * * * 总人数3240 计算公式 Calculation Formula The desired dosage in microcuries to be delivered per gram of thyroid ranged from 50~200 μCi 每g甲状腺组织的常用131I活度为2.59~4.