基质金属蛋白酶与胃癌侵袭和转移的研究进展精选.pdfVIP

World Journal of Cancer Research 世界肿瘤研究, 2015, 5, 21-26 Published Online April 2015 in Hans. /journal/wjcr /10.12677/wjcr.2015.52004 The Research Progress of Matrix Metalloproteinases in Invasion and Metastasis of Gastric Cancer Yali Xiong, Zheng Xiang* First Affiliated Hospital, Chongqing Medical University, Chongqing * Email: 425050668@ th th st Received: Mar. 15 , 2015; accepted: Mar. 27 , 2015; published: Apr. 1 , 2015 Copyright © 2015 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract As is known to all, the most important thing for treating gastric cancer is to prevent its invasion and metastasis, which are the most common causes of treatment failure and mortality. When in- vasion and metastasis happened, it always accompanied with the integrity destruction of the extracellular matrix and the basement membrane. And it often leads to the change of tumor cell adhesion ability and angiogenesis as well. Matrix metalloproteinases (MMPs) plays a significant role in the invasion and metastasis of gastric cancer. As a therapeutic target, the drugs affected on MMPs had reached the stage of clinical trials. I will make a simple review to introduce the role of MMPs in the invasion and metastasis of gastric cancer. Keywords Cancer of the Stomach, Invasion and Metastasis, Matrix Metalloproteinases 基质金属蛋白酶与胃癌侵袭和转移的研究进展 熊亚立，向 征* 重庆医科大学第一附属医院，重庆 * Email: 425050668@ *通讯作者。 21 基质金属蛋白酶与胃癌侵袭和转移的研究进展 收稿日期：2015年3月15 日；录用日期：2015年3月27 日；发布日期：2015年4月1 日 摘 要