磺酰脲类受体2型依赖的KATP通道在缺血预适应中的调控作用-英文PPT.ppt

Regulation and Roles of the Sulfonylurea Receptor 2-Based KATP Channels in Ischemic Preconditioning;Ion Channels Play Pivotal Roles in Cardiac Functions and Protection; ? Noma (1983): Sarcolemmal KATP;Reviewed by Shi, Ye, Makielski (2005) JMCC 39:51; Ischemia is a disease condition where the heart has insufficient levels of oxygen and blood supply Acute myocardial infarction is a life-threatening event that can cause sudden death and heart failure Blocking KATP channels during ischemia abolishes cardioprotection (Gross Auchampach, 1992) ? The opening of KATP can re-polarize the cell membrane, reduce calcium entry and decrease ATP consumption ? MitoKATP is more likely to confer cardioprotection (Garlid et al., 1996 1997) but its molecular nature is not completely understood;Chutkow, Pu, Wada, Makielski, Burant, McNally. PNAS (2001) 98:11760 Kakkar, Ye, Shi, Makielski, McNally et al., Cir Res (2006) 98:675;The Glibenclamide-Sensitive KATP Current is Absent in the Mutant Myocytes and VSM Cells;0;1 s;Kinetics of IKATPn Differ from the Conventional IKATP;WT;Summary of Part I;; 155;140;Summary of Part II;Mutant ;Stoller, Kakkar, Shi, Makielski, McNally. (2007) JMCC 43:445;Infarct Size I-AAR%;Regulation of SUR2 Variants During Acute IPC in Male Mice;Summary of Part III;Conclusions;;Gender Difference in Cardiac Protection;Acknowledgements;;