肿瘤化疗PPT.ppt

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2018-01-25 发布于江苏
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肿瘤化疗PPT.ppt

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肿瘤化疗PPT

* CANCER CHEMOTHERAPY(Lecture Outline For Medical Students) 管忠震 Cancer Chemotherapy (1) The role of chemotherapy in cancer treatment (2) Current status of cancer chemotherapy: How effective it is? (3) Mechanism of cancer chemotherapy: a brief review (4) Difficulties in cancer chemotherapy: How to overcome? (5) New developments A Brief Review of Natural History of Cancer Normal somatic cell mutation Malignant change Cancer cell Proliferate (Mitosis) Cell mitosis: DNA Synthesis Mitosis RNA S phase M phase Cancer cell: Number Increasing Cancer in situ T Local tumor mass Local infiltration extension Locally advanced N Lymphatic spread: LN M Hemangial (Systemic spread): Remote metastasis Role of Chemotherapy in Cancer Treatment (1) Metastatic Cancer: Palliative or Curative Chemotherapy (2) Adjuvant Chemotherapy: to erradicate or control micro-metastasis (3) Neo-adjuvant Chemotherapy (Induction Chemotherapy) to make Surgery of RT possible to alleviate surgical damage to eradicate micro-metastasis (4) Hematological Malignancies: Primary Treatment In Localized or Regional Cancer CasesMicro-Metastasis May occur(Sub Clinical Metastasis) Efficacy of Chemotherapy to Cancers Chemotherapy Curable Cancers Childhood: ALL 70% NHL 50% Burkitt’s Lymphoma 50% Wilm’s Tumor 50% Ewing’s Sarcoma 50% Embrynal 50% Rh