胰岛素抵抗、糖尿病与冠心病（英文）PPT.ppt

Epidemiology of Insulin Resistance, Diabetes Mellitus, and Coronary Heart DiseaseSteven Haffner, MD;Adapted from World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva: World Health Organization:1999:52.;Developed;Hospitalization Costs for Chronic Complications of Diabetes in the US;Annual CHD Deaths per 1000 Persons;Nondiabetes;WOMEN;WOMEN;Influence of Multiple Risk Factors* on CVD Death Rates in Diabetic and Nondiabetic Men: MRFIT Screenees;Putative Mechanism for Increased Atherosclerosis in Type 2 Diabetes; + = moderately increased compared with nondiabetic population ++ = markedly increased compared with nondiabetic population – = not different compared with nondiabetic population;Differences in HDL Cholesterol and LDL Size by Diabetic Status in Women and Men;Strategies for Reduction of Diabetic Complications;Incidence Rates of MI and Microvascular Endpoints by Mean Systolic Blood Pressure: UKPDS;Incidence Rates of MI and Microvascular Endpoints by Mean Hemoglobin A1c: UKPDS;Plasma Insulin and Triglycerides Predict Ischemic Heart Disease: Quebec Cardiovascular Study;Plasma Insulin and Apolipoprotein B Predict Ischemic Heart Disease: Quebec Cardiovascular Study;LDL Particle Size and Apolipoprotein B Predict Ischemic Heart Disease: Quebec Cardiovascular Study;Baseline Anthropometric Variables and Cardiovascular Risk Factors in Subjects with Normal Glucose Tolerance at Baseline According to Conversion Status at 8-Year Follow-up: San Antonio Heart Study;“Ticking Clock” Hypothesis;Hemoglobin A1;Stepwise Selection of Risk Factors* in 2693 White Patients with Type 2 Diabetes with Dependent Variable as Time to First Event: UKPDS;Criteria for Accepting Cardiovascular Risk Factor Management as Similar in Diabetic and CHD Subjects;Incidence of Fatal or Nonfatal MI During a 7-Year Follow-up in Relation to History of MI in Nondiabetic vs Diabetic Subjects: East-West Study;Incidence of Fatal or Nonfatal Str