中科院细胞与分子免疫学课程chapter11PPT.ppt

Section IV Effector Mechanisms of Immune Responses;Chapter 11 Cytokines;Nomenclature:;2. Because many cytokines are made by leukocytes and act on other leukocytes, they are also called interleukines. 3. In this book, we use term cytokine, which does not imply restricted cellular sources or biologic activities. ;General Properties of Cytokines:;3 Cytokine Actions;Redundancy More than one cytokine can do the same thing (IL-2, IL-4,IL-5) ;Synergy Two or more cytokines cooperate to produce an effect that is different or greater than the combined effect of the two cytokines when functioning separately (IFN-g and TNF) ;Antagonism Two or more cytokines work against each other (IL-10 and IFN-g);;Functional Classification of Cytokine;3. Stimulators of hematopoiesis.;Cytokine Receptors;Five families of Cytokine Receptor Structure;1. Type 1 cytokine receptors; Among type 1 cytokine receptor , three subtype family exit:;2.Type II cytokine receptors;3. Ig superfamily family.;4. TNF recptors;5. Seven-transmembrane a – helical receptors;Cytokines in Immunity;Cytokines that mediate and regulate innate immunity;Tumor Necrosis Factor (TNF): 1.Definition: TNF-a, a substance present in the serum of animals with bacterial endotoxin that caused the necrosis of tumors in vivo. 2.Production, Structure, Receptors ;Structure;Receptor: ;3. Signal ;4.Biologic Actions;4.Biologic Actions;IL-1;Receptor;4. Biologic Actions;Chemokines:;;Production:;Receptor:;Chemokines and receptor;Biologic Actions:;T： CCR7; DC：CCR7; B： CCR7 、CXCR5; TH：CXCR5 T区HEV：CCL21; B滤泡区HEV：CXCL13 T与DC在T区作用，分化效应细胞; TH与B在B区作用，协助Ab产生和类别转换。;IL-12;Structure, production, Receptors;Signal;JAK/STAT;Biologic Actions:;Type I Interferons (IFNs);Receptor: IFN-a and IFN-b bind to the same cell surface receptor and induce similar biologic responses.;Biologic Actions;Interleukin-10;Receptor: type II cytokine receptor.;Biologic Actions: IL-10 inhibits the production of IL-12 by activated macrophages and dendritic cells. IL-10 inhibi