CH12 ANOVA of repeated measurement data. ppt Medical Statistics医学统计学 教学课件.pptVIP

Chapter 12 ANOVA of Repeated Measurement Data §1 Character of Repeated Measurement Data Content Data characteristic Analysis of two factors and two levels Analysis of two factors and several levels Notices Objective: Inference the effects of treatment, time, and treatment*time on experimental objects Character of data: treatment factor: g （≥1 ）levels and n experimental objectives in each level, add up to gn experimental objectives. time factor: m valves at m time in each experimental objective, add up to gnm valves. Method: ANOVA I premeasure-postmeasure design It is particular case in repeated measurement data and is also called single group premeasure-postmeasure design. g=1, m=2. Differences with paired test: 1.Two experimental units in the same pair in the paired test may be managed at random. Two experimental units can be observed at the same time. We can compare the difference of the group. The results of premeasure-postmeasure design cann’t be observed at the same time although it can be arranged at pre-post experiment. But in substance it is compared with the difference of pre-post experiment. We infer the treatment to be effective on condition that we assume the time don’t affect the results. paired/matched t-test requires the results of two experimental units in the same pair and difference to be fit for independent. The difference obeys to normal distribution. Two results of premeasure-postmeasure design are common not to independent with differences. The first time result is negative correlation to the difference in most cases. Table 12-1 as follows, the correlation of diastolic pressure before treatment with the difference is 0.602. 3.It is inferred the effective of treatment by average difference in paired design. While we can analyze average difference and analyze correlation and regression in premeasure-postmeasure design. Calculate table 12-1 as follows, the correlation coefficient of diastolic