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Oxygen radicals induce human endothelial cells to express GMP140 and bind neutrophils..pdf英文资料.pdf

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Published February 15, 1991 Oxygen Radicals Induce Human Endothelial Cells to Express GMP-140 and Bind Neutrophils K a m a l a D. Patel,* G u y A. Zimmerman,~ Stephen M. Prescott,*~ Rodger E McEver,§ and T h o m a s M. MeIntyre*¢ Departments of * Biochemistry and ¢ Medicine and the Nora Eccles Harrison CardiovascularResearch and Training Institute, Universityof Utah School of Medicine, SaltLake City, Utah 84112; and § Departmentof Medicine, St. Francis Medical Research Institute, Universityof Oklahoma Health Sciences Center, CardiovascularBiology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104 Abstract. The initial step in extravasation of neutro- was inhibited by antioxidants, and, when peroxides phils (polymorphonuclear leukocytes [PMNs]) to the were the oxidants, was inhibited by intracellular iron extravascular space is adherence to the endothelium. chelators. D o We examined the effect of oxidants on this process Granule membrane protein-140 (GMP-140) is a w n by treating human endothelial cells with H202, membrane-associated glycoprotein that can be translo- l o t-butylhydroperoxide, or menadione. This re