木薯淀粉微球合成工艺条件的研究.docVIP

广 西 大 学 毕业论文 课题 木薯淀粉微球合成 工艺条件的研究 学 院 化学化工学院 专 业 化学工程与工艺 班 级 2008级(2)班 学 号 姓 名 指导教师 年 月 日  摘 要 淀粉微球是一种新型功能性高分子微球材料作为药物载体在医药领域已经得到了实际的应用在废水处理等领域应用前景。其中淀粉微球粒径的大小对其应用有很大影响，工艺研究成为人们关注的热点。的工艺条件:淀粉为，比为，交联剂BA浓度为，引发剂为以浓度变化均以总水量为25 ml（即25 g）为基准μm，粒径主要分布在6~30 μm。得到的淀粉微球呈球形，表面粗糙多孔，作为药物载体具有广阔的应用前景。 关键词:木薯 淀粉微球 反相乳液 Study on the preparation of cassava starch microspheres Abstract Starch microspheres is a novel functional polymer microspheres, with the advantages of biodegradable, non-toxic, non-immunogenic, etc. It has been extensive and practical applications in the medical field as a carrier for targeted drug, and its application prospects will be very broad in the field of wastewater treatment and accumulation of heavy metals recovery. The particle size of starch microspheres has a great influence in its application. In this paper, the starch microspheres were prepared from cassava starch through reversed phase emulsion system, using Span-80 and Tween-80 as emulsifier, whiteruss as oil phase, N,N-methylene-bisacrylamide as crosslinker, Ammonium persulfate as initiator. Using the diameter of CCSM as response variable, cassava starch concentration, oil and water phase volume ratio, the amount of crosslinking agent, initiator dosage and the amount of emulsifier were study by single factor design experiment. The optimum polymerization conditions were decided by experiments as follows: cassava starch concentration of 10%, water and oil phase volume ratio of 8:1, the crosslinking agent MBA concentration of 0.8%, initiator over the ammonium sulfate concentration of 1.2%, emulsifier concentration of 14.4%(The above concentration changes are based on the total amount of water 25 ml (25 g) as a benchmark). The average particle size of the starch microspheres prepared under the optimum conditions is 10.2 μm, the particle size is mainly distributed in 6