ICAM-1和PCNA在肺癌中的表达及其意义.pdfVIP

1834 重庆医学2007年9月第36卷第18期 ·论 著 · ICAM-1和PCNA在肺癌中的表达及其意义 周人杰 ，‘陈 伟 “，阂家新，，张国强’，戴纪纲 ，‘肖颖彬2△ (第三军医大学析桥医院:1胸外科;2.心血管外科，重庆400037; 3重‘庆市渝北区中医院外科，重庆40112的 摘 要:目的 了解ICAM-1,PCNA在肺疾中的表达状况及手术前后sICAM-1的变化趋势，探讨ICAM-1,sICAM-1,PCNA 在肺瘩鉴别诊断、病情利断及转移中的作用。方法 本实验以肺疮手术切除标本，正常肺组织、肺癌及肺良性病变患者血清为研 究甘象，采用免痰组化、踌联免痰吸附试脸方法进行研充.结果 肺疮中存在ICAM-1,PCNA过表达.肺痛晚期有淋巴结转移 的肺癌组织ICAM-1及血清中sICAM-1均明显增高。结论 检测ICAM-1,.ICAM-1水平有助于判断病情及手术治疗效果，与 PCNA联合检浏，可能意义更大。 关键词:ICAM-1;PCNA;sICAM-1;肺痛 中用分类号 R734.2:R730.21 文献标识码:A 文章编号:1671-8348(2007)18-1834-02 ClinicalsignificanceofIntercellularadhesionmolecule-1andPCNAinlungcancer ZHOURen-jie,CHENWei,MINJia-sirs,etal (1.DepartmentofThoracicSurgery12.DepartmentofCardiovascularSurgery,XingiaoHospital, ThirdMilitaryMedicalUniversity,Chongging400037.China;3.DepartmentofCrneralSurgery, YubeiDistrictHospitalofTraditionalChineseMedicine,Chongging401120.China) Abstract:ObjectiveToanalyzewhetherornotexpressionlevelsofICAM-1,sICAM-1andPCNAinlungcancerhelptopre- dicttheclinicalstagingoflungcancer.MethodsFrom2003to2005,47samplesoflungcarcinomatissuesand17samplesofset- umswerestudied,11otherlungdiseasepatientstissueswerecontrasted.PCNA,cellsurfaceICAM-1andsICAM-1wereana- lyzedbyimmunohistochetnistryandELISAmethod.ResultsPCNAandICAM-1over-expressedinlungcancer.Theconcentration ofsICAM-1inthecancerpatientsweresignificantlyhigherthanthatofthecontrolgroup.Inaddition,comparedwithpreoperative level,theconcentrationofsICAM-1intheradicaloperationgroupwassignificantlydecreasedafter14d(PGO.01);whereas,the explorationgrouphadlittleornovariouschange(PO.05).Conclusion Over-expressionofICAM-1andsICAM-1inlungcancer patientsarethussug