白花丹素抗肿瘤活性及其作用机制研究进展-tumor.pdf

肿瘤2014 年10 月第34 卷第10 期　TUM OR Vol. 34, October 2014　　 957 DOI: 10.3781/j .issn.1000-7431.2014.55.224 Copyright© 2014 by TUM OR Review 综述 · 白花丹素抗肿瘤活性及其作用机制研究进展 1 2 1 乔　涵 ，王婷玉 ，汤亭亭 上海交通大学医学院附属第九人民医院1. 骨科；2 . 药剂科，上海　200011 [摘要]　研究发现，白花丹素在体内和体外对多种肿瘤细胞均具有明显的生长抑制作用。白花丹素还可通过调节 骨内微环境，阻断肿瘤转移的 “恶性循环”，抑制肿瘤细胞骨转移。本文阐述了白花丹素对多种肿瘤细胞的抑制作 用及其机制，并以高骨转移潜能的恶性肿瘤为例，阐述了白花丹素的抗肿瘤作用机制及其作用靶点。目前，大部 分动物实验仍采用白花丹素腹腔内给药的方式，但已有学者研发了可明显增强白花丹素抗肿瘤活性的新型高分子 缓释给药体系。随着对白花丹素抗肿瘤活性及其作用机制的认识不断深入，今后可通过对白花丹素的化学结构进 行优化设计，以进一步提高其抗肿瘤活性。 [关键词]　肿瘤；白花丹素；肿瘤抑制；骨转移 [中图分类号]　R730.52 [文献标志码] A [文章编号]　1000-7431 (2014) 10-06-0957 Advances in tumor suppression by plumbagin and it mechanism 1 2 1 QIAO Han , WANG Ting-yu , TANG Ting-ting 1. Department of Orthopedic; 2. Department of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China [A BST RA CT]　Recent studies have demonstrated that plumbagin has significant suppressive effect on the proliferation of various tumor cell lines in vivo and in vitro . Plumbagin can also inhibit the metastasis of tumor cells by blocking up the “vicious cycle” of tumor metastasis through regulating the bone microenvironment. This paper reviews the advances in inhibition effect of plumbagin on many tumor cell lines and the related mechanism, especially illustrating the underlying antitumor mechanism and functional targets of plumbagin in the malignant tumors with high metastatic potential. Currently, the majority of the animal experiments apply systematic drug delivery via intraperitoneal injection of plumbagin; whereas the novel sustained-release drug delivery systems, which are based