外文翻译---基于OLED的聚丙烯生物光盘传感器.docxVIP

外文资料原文OLED-Polypropylene Bio-CD SensorSrikanth Vengasandra, Yuankun Cai, David Grewell, Joseph Shinar, and Ruth Shinarc Department of Agricultural Biosystems Engineering Ames Laboratory - USDOE and Department of Physics AstronomyMicroelectronics Research Center and Department of Electrical and Computer Engineering Iowa State University, Ames, IA 50011, U.S.AABSTRACTWith the goal of developing microfluidic platforms for sensing applications, flash-free micro patterns were embossed in polypropylene surfaces with ultrasonic heating for a biosensing application. The embossed features were designed to act as reservoirs, valves, and reaction chambers to allow, in combination with a compact sensing platform, the monitoring of analyte levels using a standard PC-CD player. To generate the compact sensor, as an example, we chose the photoluminescence (PL)-based detection of lactate and glucose using an OLED-based sensing platform. Once embossed, the surface energy of the plastic substrate was chemically modified to make it hydrophilic. Reagents, placed in separate reservoirs, were directed through burst valves towards a reaction chamber via CD rotation. Lactate or glucose were monitored by measuring the effect of the related dissolved oxygen level on the PL decay time of an oxygen-sensitive dye, following analyte oxidation catalyzed by a suitable specific oxidase enzyme. The results demonstrate the potential of integrating OLEDs as excitation sources in PL-based sensors with microfluidic CD- based platforms, including for simultaneous multiple analyses.Keywords: Organic light-emitting diode, OLED, lab-on-a-CD, glucose sensor, lactate sensor1. INTRODUCTIONBiomedical micro electromechanical system (MEMS)-based sensing platforms fabricated on plastic substrates have the potential of e.g., being low cost, disposable, cross-contamination free, and sensitive. Additionally, such sensors show promise for high throughput and multianalyte detection. The advantages of such a lab-on-