yyl读书报告.pptxVIP

读书报告 NO.3 Surface-induced spreading phenomenon of protein clusters报告人---指导老师---2011-09-08Protein AdsorptionAdsorbe behaviorApplicationIndividual behavior医学材料 Orientation. Side-on or head-on? Conformational changes生物传感器Ensemble behavior Structure of the protein layer Monolayer or multilayer? Lateral interaction Cooperative effects Overshooting adsorption Aggregation 生物分离…………Protein Aggregation Protein ClusterMechanism of AggregationJounal ArticalTwo-dimensional assembles of aggregated protein monolayers on a sufaceSeveral hundredsSFM images of ezrin on a solid-supported membraneA few monomersAFM image of lysozyme on graphiteA highly regularly order manner which is referred to as two-dimensional surface crystalTwo-dimensional ordered organization AFM image of of annexin A5 on silica-SLBsProtein Aggregation Protein ClusterMechanism of AggregationJounal ArticalSurface induced process1. Surface Diffusion Adsorbe as monomers Diffuse on the sufface Form clustersProtein Aggregation Protein ClusterMechanism of AggregationJounal ArticalSurface induced process1. Surface Diffusion Adsorbe as monomers Diffuse on the sufface Form clustersProtein in solution Adsorbed proteinSurface diffusionProtein clusterProtein Aggregation Protein ClusterMechanism of AggregationJounal ArticalSurface induced process1. Surface Diffusion Adsorbe as monomers Diffuse on the sufface Form clusters2. Cooperative Adsorption Adsorbe as monomers Attracted to the ege of cluster Directly adsorbe adjacent to clusters and insert into itProtein Aggregation Protein ClusterMechanism of AggregationJounal ArticalSurface induced process Aggregates in solution1. Surface Diffusionmonomer Adsorbe as monomers Diffuse on the sufface Form clusters2. Cooperative Adsorption Adsorbe as monomers Attracted to the ege of clusteraggregate Directly adsorbe adjacent to clusters and insert into itProtein AggregationProtein AggregationAuthor Protein Cluster Mechanism of AggregationJounal ArticalAb