胰岛素依赖型糖尿病ppt课件.pptVIP

Type 1 Diabetes- - IDDMInsulin Dependent Diabetes Mellitus TEAM - 窦甍 李德全 李帅 刘惠君 刘晓云 罗黎希 Contents What is IDDM Factors Inducing IDDM Virus Infection HLA expression Mechanism of IDDM CD4+ T cell response CD4+ T cell related response Th0 cells mainly differentiate into Th1 cells, causing Th1/Th2 unbalance. Th1 cells produce IFN-γ TNF-α, inducing expression of Fas protein on islet βcell, and FasL expression on CTL or macrophage(IL-1β , NO, RNIs). IFN–γ can activate NK cell ,which then hurt the target cells (β cell) with specific Ag . IL-2 IL-12 Th2 antagonizes Th1 effects. IL-4 and IL-10 can strongly inhabit Th-1 to produce IFN-γ, which can decrease the level of isletitis and improve β cells to produce insulin, to decrease the morbidity of IDDM CD8+ T cell response Humoral Immunity Insulin – Insulin Ab (IA) Insulin receptor – Anti-insulin receptor Ab Islet cell surface Ag (ICA)- Islet cell surface Ab Glutamate decarboxylase (GAD) – Anti-glutamic acid decarboxylase Ab (GADA) Relationship Manifestation Complications Complications Therapy Dec. 7th, 2007 Regeneration of β cells LOGO What is IDDM ◇ Factors Inducing IDDM ◇ Immune Mechanism Manifestations Complications Therapy IDDM Insulin Dependent Diabetes Mellitus Type 1 diabetes(T1D), also named IDDM, is one of the most common autoimmune disease, affecting almost 20 million people worldwide. Factors Self Ag changes Immune Response Disease Breaking Type 1 Diabetes Or IDDM. NOD Children Adolescent Insulin-dependent Heredity Virus Infection Environmental Factors Recognition of specific self islet βantigens Effects of immune cells molecules Breaking of Immune tolerance Autoimmune disease HLA-DQ β57 Asp Neutral AA HLA-DQ α52 Arg Coxsackie B virus Rubella virus Mumps virus Cytomegalovirus Epstein-Barr virus Etc. Chemicals Medicament Heredity Virus Environment Changes of self-Ag into non-self-A