The Role of the Visceral Mesoderm in the Development of the Gastrointestinal Tract英文文献.pdfVIP

GASTROENTEROLOGY 2009;136:2074–2091 G B A A S S T I R C R O A E V E N I REVIEWS IN BASIC AND CLINICAL N D E T W E C S R L O I I N N GASTROENTEROLOGY L O I C G A Y L John P. Lynch and David C. Metz, Section Editors The Role of the Visceral Mesoderm in the Development of the Gastrointestinal Tract VALÉRIE A. MCLIN,* SUSAN J. HENNING,‡ and MILAN JAMRICH§, *Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, §Department of Cellular and Molecular Biology, and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas; and ‡Departments of Medicine and Cell and Molecular Physiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina The gastrointestinal (GI) tract forms from the en- served from invertebrates to vertebrates, including the doderm (which gives rise to the epithelium) and role of the visceral mesoderm (VM). Understanding the the mesoderm (which develops into the smooth mus- role of the VM in development may help orient cell-based cle layer, the mesenchyme, and numerous other cell therapy research. types). Much of what is known of GI development has been learned from studies of the endoderm and its Overview of GI Development derivatives, because of the importance of epithelial biology in understanding and treating human dis- Development of the vertebrate GI tract, and of the