Central Insulin Signaling Is Attenuated by Long Term Insulin Exposure via Insulin Receptor Substrate 1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation英文文献.pdfVIP

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Central Insulin Signaling Is Attenuated by Long Term Insulin Exposure via Insulin Receptor Substrate 1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation英文文献.pdf

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Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation Christopher M. Mayer and Denise D. Belsham Endocrinology 2010 151:75-84 originally published online Nov 3, 2009; , doi: 10.1210/en.2009-0838 To subscribe to Endocrinology or any of the other journals published by The Endocrine Society please go to: //subscriptions/ Copyright © The Endocrine Society. All rights reserved. Print ISSN: 0021-972X. Online D I A B E T E S - I N S U L I N - G L U C A G O N - G A S T R O I N T E S T I N A L Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation Christopher M. Mayer and Denise D. Belsham Departments of Physiology (C.M.M., D.B.B.) and Obstetrics and Gynaecology and Medicine (D.D.B.), University of Toronto, and Division of Cellular and Molecular Biology (D.B.B.), Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada M5S 1A8 Central insulin signaling is critical for the prevention of insulin resistance. Hyperinsulinemia con-