Interactions among dendritic cells, macrophages, and epithelial cells in the gut implications for immune tolerance英文文献.pdfVIP

Available online at Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance 1 2 1 Maria Rescigno , Uri Lopatin and Marcello Chieppa The intestine is described as an immune privileged site where pathogenic and contribute malabsorption, inflammatory immunoregulatory mechanisms simultaneously defend against bowel disease, and colorectal cancer [2]. How can the pathogens, yet preserve tissue homeostasis to avoid immune- intestinal immune system handle this load of infor- mediated pathology in response to environmental challenges. mation is not completely understood, but it is becoming Additionally, tolerance to ingested antigens promotes the clear that the interaction between luminal bacteria, development of systemic unresponsiveness towards the same epithelial cells, and immune cells is crucial to preserve antigens. It is increasingly clear that this tolerance is a complex intestinal homeostasis. In this review, we will focus on process that derives from the coordinated action of both three important cell types: epithelial cells, dendritic canonical immune and non-immune cells at mucosal sites, cells, and macrophages that via a coordinated action including dendritic cells, macrophages and epithelial cells. help keeping peace at mucosal surfaces but are ready to Recent evidence suggests that dysregulation in gut-induced fight, when needed. tolerance and commensal bacterial handling affects both local and systemic compartments and contributes to autoimmune