盐酸丙帕他莫用于无痛人流术复合靶控输注异丙酚- 中文word文档库.docVIP

盐酸丙帕他莫用于人工流产术复合靶控输注异丙酚的效应室靶浓度( 本文档由【中文word文档库】提供，转载分发敬请保留本信息； 中文word文档库免费提供海量范文、教育、学习、政策、报告和经济类word文档。 纪宏新1( ，柯昌禄1，张兴安2（1.深圳市龙岗区葵涌人民医院麻醉科，深圳市 518119；2.广州军区广州总医院麻醉科摘要　目的测定盐酸丙帕他莫用于人工流产术复合靶控输注（TCI）异丙酚的效应室靶浓度（EC50和EC95）。方法选择30例ASAⅠ级孕6~12周接受无痛人工流产术患者，术前30min静脉滴注盐酸丙帕他莫2g，TCI异丙酚效应室靶浓度采用改良序贯法确定，根据上一例患者术中有无明显体动反应，下一例患者增加或减少0.5mg·L-1，用概率单位回归分析法计算出EC50和EC95及相应的95%可信区间（CI）。结果复合盐酸丙帕他莫2g时，异丙酚的EC50为4.81mg·L-1，95%CI为4.34~5.19mg·L-1；EC95为5.86 mg·L-1，95%CI为5.34~9.68 mg·L-1。结论复合盐酸丙帕他莫2g用于人工流产术，靶控输注异丙酚效应室靶浓度为5.86 mg·L-1较适宜。 关键词JI Hongxin, KE Changlu (Dept. of Anesthesiology, Kuichong Peoples Hospital of Longgang District Shenzhen City Guangdong Province,Shenzhen 518119,China) ZHANG Xingan (Dept. of Anesthesiology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China) ABSTRACT OBJECTIVE： To determine the effect-site concentration of propofol target-controlled infusion (TCI) when combined with propacetamol hydrochloride in 50% and 95% of patients (EC50 and EC95) undergoing induced abortion of indolence. METHODS：　T ASA Ⅰ patients, at 6 to 12 weeks of pregnancy undergoing induced abortion of indolence were enrolled in this study. Propacetamol hydrochloride 2g was given to the patient intravenously preoperation 30 minutes. The target effect site concentration of propofol was determined by the modified Dixon’s up-and-down sequential trial. If the previous patient movement or no movement response, the next target effect site concentration of propofol was increased or reduced by 0.5 mg稬-u1. Probit analysis was used for calculating EC50, EC95 and 95% confidence interval (CI). RESULTS：　he EC50 of propofol was 4.81 mg·L-1 (95%CI was 4.34-5.19 mg·L-1) and EC95 of propofol was 5.86 mg·L-1 (95%CI was 5.34-9.68mg·L-1). CONCLUSION：　.86 mg·L-1 when combined with propacetamol hydrochloride 2g undergoing induced abortion of indolence. KEY WORDS 　Propacetamol hydrochloridePropofol；Induced abortion；Dose-response relationship 盐酸丙帕他莫乙酰氨基酚的前体药物，进入人体后可迅速被血浆酯酶水解成游离状态的对乙酰氨基酚而发挥镇痛作用具有镇痛作用强，不