三种抗阳性菌药物比较资料.pptVIP

国内葡萄球菌对万古霉素保持 敏感率 全国主要抗生素对葡萄球菌属敏感率监测 (Mohnarin) 2008 (n=10409) (n=5981) 肖永红，王 进，赵彩云等，2006—2007年Mohnarin细菌耐药监测,中华医院感染学杂志2008,18(8):1051-1056 利奈唑胺目前的MIC分布情况图 2200 0 400 800 1200 1600 2000 0.12 0.25 0.5 1 2 4 ≥8 利奈唑胺MIC (μg/ml) 株数 (N) 6株 4株 2007年ZAAPS细菌耐药性监测结果1 万古霉素对于 金葡菌的MIC90 仅为1mg/L Jones RN ,Kohno S, Ono Y, et al. ZAAPS International Surveillance Program(2007) for Linezolid resistance: results from 5591 Gram-Positive clinical isolates in 23 countries.Diagnostic Microbiology and Infectious Disease 2009, 64:191-201. * 欧洲43家医院监测结果 Bacteria Year Strain No Vancomycin Teicoplanin MICr MIC90 MICr MIC90 S. aureus 2005 337 0.25-2 1 0.12-8 2 2006 220 0.5-2 1 0.25-4 1 2007 131 0.5-2 1 0.25-4 1 2008 69 0.25-2 1 0.25-4 1 CoNS 2005 93 0.25-4 2 0.25-16 4 2006 81 0.5-2 2 0.25-32 8 2007 81 0.5-2 2 0.25-8 4 2008 91 0.25-2 2 0.12-8 4 S. pyogenes 2005 41 0.25 0.25 Nt Nt 2006 - - - - - 2007 146 0.12-0.5 0.25 0.03-4 0.03 2008 54 0.12-0.25 0.25 0.03-1 0.03 Enterococci 2005 301 0.125-256 256 0.06-256 64 2006 - - - - - 2007 72 0.25-2 2 0.5-2 0.25 2008 107 0.25-128 2 0.25-128 0.25 ECCMID 2009, p1620 ECCMID 2009, 1637 * 万古霉素和利奈唑胺治疗院内肺炎疗效相当 在利奈唑胺提交给FDA的临床报告中详细描述了治疗医院内肺炎的临床研究.该研究用万古霉素和利奈唑胺进行对照显示万古霉素可评价临床疗效为60%，利奈唑胺可评价临床疗效57%，二者疗效相当，利奈唑胺疗效并未超越万古霉素。 0 10 20 30 40 50 60 利奈唑胺 万古霉素 利奈唑胺 万古霉素 ZYVOX 产品说明书信息 Distributed by Pfizer PharmaciaUpjohn Company Divison of Pfizer Inc,NY,NY10017 LAB-0319-16.0 % linezolid versus Vancomycin or Teicoplanin for Nosocomial Pneumonia: A Meta-Analysis AC. KALIL, M. H. MURTHY , E. HERMSEN , et al. Methods: Prospective, randomized trials which tested linezolid vs. vancomycin or teicoplanin for treatment of NP were included. Heterogeneity was analyzed by I2 and Q statistics. Relative Risks (RR) were based on the Mantel-Haenszel method. Outcomes analyzed included clinical cure (CC), microbiologic eradication (ME), and side effects. Results: 8 linezolid trials (6 vancomycin, 2 teicoplanin) were included (N=853). The linezolid v