osahs患者外周血中血清mpo的水平及其意义word论文.docxVIP

30）研究对象MPO水平明显高于非OSAHS对照组MPO水平（P=0.0000.05）；三组OSAHS患者血清中MPO水平差异有统计学意义（P0.05）2.血清MPO水平与OSAHS患者的AHI、LSaO2 、BMI存在相关性（P＜0.05 ），且血清MPO水平与AHI（r= 0.677）、LSaO2 （r= -0.541）显著相关；MPO血清水平与各组研究对象的性别、年龄无关。结论中重度OSAHS患者血清髓过氧化酶（MPO）水平明显增加，提示MPO与OSAHS 关系密切，与疾病严重程度相关，与患者性别、年龄无关。MPO可能参与了OSAHS 的相关病理过程，尤其是后者引发心血管系统疾病的相关病理生理过程。中重度OSAHS患者并发冠心病的风险性可能高于轻中度OSAHS及非OSAHS；MPO在重症OSAHS患者或OSAHS患者病程后期罹患心血管的风险性预测可能具有一定的作用。关键词阻塞性睡眠呼吸暂停低通气综合征；氧化应激；炎症反应；MPO2AbstractObjective:BycomparingserumMPOlevelintheperipheralbloodofadult mild,moderateandsevereOSAHSpatientsandnon-OSAHS(control)healthy adaults,discussestherelationshipbetweenOSAHSpatientswith atherosclerosis,preliminaryunderstandingofOSAHSpatientscomplicated withcoronaryheartdiseaseriskandMPOintheroleoftheOSAHSpatients complicated with coronary heart disease (CHD) risk assessment. Methods:SelectionbetweenApril2012andNovember80casesinthe peopleshospitalofhunanprovinceduringtheperiodofsnoringadults, 20patientsfromoutpatientmedicalexamination,accordingtotheEpworth sleepinessscaleandBerlinsleepqualityassessmentquestionnaire resultsinOSAHSnormalcontrolgroup,morethan60casesresearchobject forthehospitalotolaryngologyheadandnecksurgeryhospitalized patientsduringthesameperiod,accordingtotheresultofsleep respirationmonitoringrespectivelyinmildOSAHSgroup,moderateOSAHS group,thesevereOSAHSgroup,eachgrouphas20casesofpatients.All subjectswerediagnosedwithoutclearlyacuteorsevereinfection, cerebrovasculardisease,peripheralvasculardisease,recentsurgery, malignanttumor,liverandkidneydysfunction,lungdisease,autoimmune disease,severetrauma,thyroidfunction,tobaccoandalcoholaddiction. AllOSAHSgroupresearchobjectlineESSandBerlinsleepquality assessmentquestionnaire,patientswithOSAHSgrouplinesofPSG monitoringfastingvenousbloodwaspumpingelbow,themorningafter30 minutesintotheupperserum,centrifugalafterputintotherefrigerator-80oCcryopreserved,forallsamplescollectedafterthecompletionof thespecialistbyELISAone-timebatchdeterminationofMPOlevelineach studyperipheralblood.AnalysisofM