鼻咽癌流行病学研究进展幻灯片.ppt

鼻咽癌流行病学研究进展;癌症---头号杀手！;1990-2000年过去10年全球范围癌症流行趋势;过去30年我国癌症流行趋势;Regional and spatial distribution in the world of nasopharyngeal carcinoma;Intermediate rates were local inhabitants;Incidence of Nasopharyngeal Carcinoma in Some Cancer Registries of Five Continents in 1998-2002 (N,1/105);Regional and spatial distribution in China; Racial distribution;Inuits from Greenland ;Tanka Boats in Hong Kong ;Incidence of Nasopharyngeal Carcinoma in the different races in the same areas;Distribution of pathological type in different races ;Familial aggregation;Ye-liang family;Time tendency ;Time trends in average annual age-standardized (per 100 000 person-years) in Hong Kong and Sihui, China;The ultimate goal of cancer epidemiology;Natural history of cancer and levels of prevention;Risk factors ; Age- and Sex-adjusted hazard ratio (HR) and 95%CIs of nasopharyngeal carcinoma by status of Epstein-Barr virus serological tests among 18,443 at recruitment (1987-2007) ; Salty fish and pickled food ;Smoking and drinking; Effect of hereditary susceptibility;Traditional Chinese Medicine ;Professional exposure;Trace element;Normal nasopharyngeal epithelium;Approaches may be used to reduced or eliminate exposure to a hazard risk factor of NPC;Screening of nasopharyngeal carcinoma;Screening It involves application of a relatively simple and inexpensive test to asymptomatic subjects in order to classify them as being likely or unlikely to have the disease which is the object of the screen. The ultimate objective of screening for a particular cancer is to reduce mortality from that disease among the subjects screened.;Screening requires:;Screening requires:;Sensitivity, specificity and predictive value of a screening test;Fig. 3 Distribuition of results from a screening test in disease-free and disease–affected individuals： (a) ideal distribution without overlap; (b) overlap of the distribution with the inevitable tradeoff of sensitivity and specificity. ;Acceptability and costs;Suitable