高度脂溶性钙离子拮抗剂在高血压动脉硬化中的应用医学课孙宁玲幻灯片.pptVIP

Several CCBs, including nifedipine, have been shown to be effective in slowing the development of atherosclerotic plaques in animals fed a high-cholesterol diet (Henry P et al. J Clin Invest 1981). Subsequently, trials have been conducted to ascertain whether these effects can be replicated in humans. In the International Nifedipine Trial on Antiatherosclerotic Therapy (INTACT), patients with mild coronary artery disease (CAD) received nifedipine or placebo. In the nifedipine group, there were 28% fewer new lesions per patient than the placebo group (p=0.034), but there was no effect on pre-ex