化疗罕见严重急症及其机制PPT.ppt

化疗所致罕见严重急症概述;Published online Jan 27th, 2011Lancet Oncology;罕见：1% 严重急症：Develop as immediate life-threatening illnesses; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;循环呼吸系统急症---致命性的心律失常;处理： 立即停用该药，并及时纠正相关的水电解质紊乱，行心电监护至少24小时，予以抗心律失常药物治疗，必要时可安置起搏器。 后续化疗须谨慎选择细胞毒性药物。 ;循环呼吸系统急症---自发性气胸;循环呼吸系统急症---自发性气胸;循环呼吸系统急症---急性肺炎;循环呼吸系统急症---急性肺炎;循环呼吸系统急症---急性肺炎;循环呼吸系统急症---ARDS;循环呼吸系统急症---ARDS; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;血液系统急症---急性溶血性贫血;血液系统急症---急性血小板减少; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;消化系统急症---中性粒细胞减少性盲肠炎 ;消化系统急症---中性粒细胞减少性盲肠炎;消化系统急症---中毒性巨结肠;消化系统急症---中毒性巨结肠;消化系统急症---急性胰腺炎; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;神经系统急症----脑卒中;神经系统急症----脑卒中;神经系统急症----可逆性后白质脑病综合征 ; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;急性皮肤反应---中毒性表皮坏死;急性皮肤反应---中毒性表皮坏死;溶血尿毒综合征、血栓性血小板减少性紫癜 ;溶血尿毒综合征、血栓性血小板减少性紫癜; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;药物相关肝毒性----急性爆发性肝衰竭 ;药物相关肝毒性----急性爆发性肝衰竭 ; Cardiorespiratory emergencies Haematological emergencies Gastrointestinal emergencies Nervous-system emergencies Acute skin reactions Drug-induced hepatotoxicity Acute vascular events;急性血管事件 ;急性血管事件----急性动脉阻塞 ;急性血管