[工学]Chapter1 Introduction of Molecular Biology.ppt

Molecular Biology References Genes IX by Benjamin Lewin Molecular Biology of the Cell (4th Edition by B Alberts) Molecular Cell Biology (4th Edition by H Lodish) Molecular Biology (2nd Edition by R Weaver) 分子生物学 (Instant Notes in Molecular Biology, 2nd Edition by P Turner） Advanced Molecular Biology (by R Twyman) 现代分子生物学（朱玉贤等） Outline Chapter 1 Introduction Chapter 2 Structure of Genome Chapter 3 DNA Replication Chapter 4 Biosynthesis of RNA Chapter 5 Biosynthesis of Protein Chapter 6 The Control of Gene Expression Chapter 7 The polymerase chain reaction Chapter 8 Study gene structure and genomes Chapter 1 Introduction 1. Definition of Molecular Biology 2. History of Molecular Biology and Central dogma 3. Relationship between Molecular Biology and other disciplines 4. Prospect of Molecular Biology 1.1 Definition of Molecular Biology The attempt to understand the biological phenomena in molecular terms. The study on the process of DNA replication, transcription, translation and expression regulation and related proteins or enzymes. Molecular biology is the study of genes and their activities at the molecular level, including transcription, translation, DNA replication, recombination and translocation. --- Robert Weaver Molecular biology seeks to explain the relationships between the structure and function of biological molecules and how these relationships contribute to the operation and control of biochemical processes. ---Turner et al. 1.2 Brief History of Molecular Biology Stage 1: Preparation Stage 2: Establishing and developing of contemporary Molecular Biology Stage 3: Primary understanding of the nature of life and modification of life-deep development stage Stage 4: Post-genome era From late 1900s to early 1950s ? Confirmed that protein is one of the fundamental materials of life. ? Confirmed that DNA is the nature of genetic material. By definition, the early work