溃洁灌肠液治疗Ⅱ度放射性直肠炎的临床疗效.doc

溃洁灌肠液治疗II度放射性直肠炎的临 床疗效 何违违方明治童葰 南京中医药大学第三附属医院 A的探讨溃洁灌肠液治疗n度放射性直肠炎的临床疗效。方法选取南京屮医药 大学第三附属医院肛肠科及肿瘤科2011年1月一2017年3月收治的II度放射性 直肠炎患者195例，随机分为A组、B组和C组，每组65例。A组患者给予单纯 丙药治疗，B组患者给予康复新+地塞米松灌肠治疗，C组患者给予溃洁灌肠液保 留灌肠。比较3组患者的临床疗效，治疗前后症状（腹泻、腹痛、血便）积分及 血液流变学指标［屮性粒细胞计数（NE）、红细胞沉降率、C反应蛋闩（CRP）、 丙氨酸氨基转移酶（ALT）］，并观察患者不良反应发生情况。结果C组患者治 疗总有效率高于A组和B组，B组患者治疗总有效率高于A组（P0.05）。治疗 前，3组患者腹泻、腹痛、血便积分比较，差异无统计学意义（P0. 05）;治疗 后，B组和C组患者腹泻、腹痛、血便积分低于A组，C组患者腹泻、腹痛、血 便积分低于B组（P〈0.05）。治疗前，3组患者NE、红细胞沉降率、CRP、ALT 比较，差异无统计学意义（P〉0.05）。治疗后，B组和C组患者NE、红细胞沉降 率、CRP低于A组（P0.05） 组患者NE、红细胞沉降率、CRP低于B组（P〈0. 05）， 3组患者ALT比较，差异无统计学意义（P0.05）。3组患者均未出现严重不良 反应。结论采用溃洁灌肠液治疗II度放射性直肠炎的临床疗效确切，其可更有 效改善患者的临床症状，安全有效。 关键词： 放射性直肠炎;黏膜损伤;溃洁灌肠液;治疗结果; 2017-07-10 Clinical effect of kuij ieguanchangye in the treatment of degree II radiation proctitis HE Wei-wei FANG Ming—zhi ZHANG Pei Third A ffiHat e dH o s p i t a 1 of Nanjing University of Traditional Chinese Medicine; Abstract： Objective To observe the curative effect of kuijieguanchangye in the treatment of degree II radiation proctitis. Methods A total of 195 cases of degree II radioactive proctitis patients were selected from January 2011 to March2017 in Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, which were randomly divided into group A, group B and group C, 65 cases in each group. Group A was given simple western medicine， group B was given new rehabilitation + dexamethasone enema, group C was given kui jieguanchangye. The clinical effect, clinical symptoms ( diarrhea, stomachache, bloody stool) scores and hemodynamic indexes ( NE, erythrocyte sedimentation rate, CRP，ALT) before and after treatment were compared among three groups, and the incidence of adverse reactions were observed. Results The total effective rate of group C was higher than group A, group B, the total effective rate of group B was higher than group A ( P 0. 05) ? Before treatment, no statistical ly significant differences of diarrhea, stomachache, bloody stool scores was found among the thr