以育人为中心全面提高学生的综合素质-UniversityofMinnesota.PDF

猪伪狂犬病及其综合防控 Pseudorabies and its Prevention and Control 钱平 ping Qian qq737711084) 华中农业大学动物医学院 教授/博导 Veterinary college of HZAU Professor/PhD Tutor 广西扬翔股份有限公司 兽医总监（兼） Guangxi Yangxiang Co., veterinary Director 汇 报 内 容 outline 猪伪狂犬病的病原学 Etiology of Pseudorabies 猪伪狂犬病流行现状与特点 Epidemic Status and Characteristics  2010—2015本实验室对猪伪狂犬病的流行病学检测 our lab detection of swine pseudorabies 2010-2015  猪伪狂犬病疫苗的筛选与免疫程序的制定 vaccine screened and make immune program  规模化猪场猪伪狂犬病综合防控 the prevention and control for Pseudorabies in large scale pig farms 一、猪伪狂犬病的病原学 Pathogen  猪伪狂犬病(Pseudorabies, PR)是由伪狂犬病病毒(PRV)引起的以家畜 和多种野生动物发热、奇痒及脑脊髓炎为特征的急性、热性传染病。 Pseudorabies was infected by PRV, is an acute infectious diseases, induced characterized clinical symptoms in livestock and varieties wild animals, such as fever, mad itch, encephalomyelitis,etc.  PRV为线性双股DNA分子，分子量为137-145 kb之间，G+C含量超过72%，PRV 基因组由独特长段(Unique Long Region, UL)、独特短段(Unique Short Region,US) 及位于US两侧的末端重复序列(TR) 和内部重复序列(IR) 构成。 目前有8株伪狂犬病病毒全基因组测序完成。 The PRV genome is double-stranded, linear, molecular weight between 137-145 kb. G+C 72%. PRV genome consists of a unique long segment (Unique Long Region, UL), the unique short segment (Unique Short Region, US), terminal repeat (TR) and internal repeats (IR). There is 8 strains of PRV has been full sequenced. U U L IR S TR 10K 20K 30K 40K 50K 60K 70K 80K 90K 100K 110K 120K 130K 140K PRV病毒的致病性与重要毒力相关基因 Pathogenicity and virulence-related genes 基因名称 主要功能 major functions 备注comment gene name TK基因 在神经细胞中的增殖并产生感染性粒子 主要毒力相关基因major