3-病毒总论-病毒学与病毒病PPT3.ppt

Chapter 4 Properties of virion 1. What is virion ( virus particle ) 2. Host range of virus Bacteria virus ( Bacteriophage ) Plant virus Mycovirus Animal virus Protozoal virus Invertebrate virus Insect virus Vertebrate virus Entomophilous virus ( Arbovirus ) Dengue virus Japanese enccphalitis virus Rice dwarf virus Cucumber mosaic virus Passenger virus Pathogenic virus Terms for describing virion properties Virion ( Virus particle ) Nucliocapsid Core or nucleoid ( nucleic acid + combined protein ) Capsid Capsomer Protein subunit Envelope Spikes and peplomer Form and structure of virion (1) Size and form of virus particle Geminivirus d = 18~20 nm vaccina virus = 300~400 X 170~260 nm parvovirus = 18~26 nm TMV = 20 X 300 nm watermelon mosaic virus = 15 X 760 nm (2) Structure of viral capsid Self-assembly helical symmetry icosahedron symmetry complex symmetry Principle of virus capsid formation The lowest free energy Cylinder symmetry Stereoscopic symmetry What we have learned in this chapter ? 1. The concept of virion . 2.The meaning of terms for describing virion properties: molecular weight; linear lenth; density; sedimentation coefficient ; capsid; protein subunit; capsomere; pentamers; hexmers; core; nucleoid; nucleocapsid; envelope; spikes. 3. The characteristics of different types of viral capsid structure. 4. What are the types of virion structure? Chapter 5 Virus life cycle 1. Viral invasion Adsorption to the Host Cell and Penetration Viral replication DNA virus replication RNA virus replication Release of Phage Particles lysis of host brought about by several T4 proteins e.g., endolysin attacks peptidoglycan e.g., holin produces lesion in cell membrane