β-内酰胺类抗生素（英文PPT）β-Lactam Antibiotics.pptVIP

β-Lactam Antibiotics 1. PENICILLINS 2.Cephalosporins 3.Carbapenems ( Imipenems ) 4. Monobactams ( Aztreonam) Penicillins Classification Narrow spectrum penicillins Antistaphylococcal penicillins Broad spectrum penicillins Extended –spectrum penicillins ( antipseudomonal penicillins). Mechanism of action Like all β-lactam antibiotics , inhibit the synthesis of bacterial cell wall . Through inhibition transpeptidase enzyme They are bactericidal on the actively growing bacteria. Pharmacokinetics Absorption Depending on acid stability Absorption of most oral penicillins is impaired by f