Efficient gene delivery by EGF lipoplexes in vitro and in vivo表皮生长因子脂质体在体外和体内的有效基因传递.pdfVIP

ReseaRch aRticle Efficient gene delivery by EGF-lipoplexes in vitro and in vivo Aims: In this work, we have evaluated the ability of targeted lipoplexes to enhance transgene expression in EGF receptor (EGFR) overexpressing tumor cells by using lipoplexes. Materials methods: We prepared DOTAP/cholesterol liposomes modified with EGF at 0.5/1, 1/1, 2/1 and 5/1 lipid/DNA (+/-) charge ratio by sequentially mixing the liposomes with the