Leukotriene B Receptor Mediates Intermittent Hypoxia…白三烯受体介导间歇性低氧.pdfVIP

Leukotriene B4 Receptor-1 Mediates Intermittent Hypoxia-induced Atherogenesis 1 2 2 1 1 Richard C. Li , Bodduluri Haribabu , Steven P. Mathis , Jinkwan Kim , and David Gozal 1Department of Pediatrics, University of Chicago, Chicago, Illinois; and 2Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky Rationale: Obstructive sleep apnea, which is characterized by inter- mittent hypoxia (IH) during sleep, has emerged as an independent AT A GLANCE COMMENTARY risk factor for cardiovascular disease, including atherosclerosis. Leu- kotriene B4 (LTB4) production is increased in patients with obstruc- Scientific Knowledge on the Subject tive sleep apnea and negatively correlates to hypoxic levels during Obstructive sleep apnea, which is characterized by inter- sleep, with continuous positive airway pressure therapy decreasing mittent hypoxia (IH) during sleep, has emerged as an in- LTB4 production. dependent risk factor for cardiovascular diseases. In recent Objectives: Determine the potential role of LTB4 in IH-induced athero- years, animal models have revealed that IH promotes ath- sclerosis in a monocyte cellular model and a murine model. erosclerosis. However, the molecular mechanisms underlying Methods: THP-1 cells were exposed to IH for 3, 6, 24, and 48 hours. IH-induced atherogenesis remain largely undefined. Macrophage transformation and foam