Leukotriene D participates in colonic transit disturbances…白三烯参与结肠运输紊乱.pdfVIP

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Leukotriene D participates in colonic transit disturbances…白三烯参与结肠运输紊乱.pdf

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Leukotriene D participates in colonic transit disturbances…白三烯参与结肠运输紊乱.pdf

GASTROENTEROLOGY 1992;102:149-156 Leukotriene D, Participates in Colonic Transit Disturbances Induced by Intracolonic Administration of Trinitrobenzene Sulfonic Acid in Rats LAURENT PONS, MARIE-THÉRÈSE DROY-LEFAIX, and LIONEL BUENO Department of Pharmacology-Toxicology, Institut National de la Recherche Agronomique, Toulouse, and Institut Henri Beaufour, Le Plessis-Robinson, France The effects of colonic inflammation induced by GR 32191B, did not show any improvement in co- trinitrobenzene sulfonic acid and influence of pre- lonic transit after trinitrobenzene sulfonic acid ad- vious treatment with specific antagonists of inflam- ministration. Previous injection of the specific matory mediators (platelet-activating factor, leuko- platelet-activating factor receptor antagonists, BN trienes, prostaglandins, and thromboxanes) on 52021 or BN 50730, was also unable to restore a nor- colonic transit were examined in conscious rats mal marker excretion profile after administration which were permanently fitted with an intraco- of trinitrobenzene sulfonic acid. It is concluded that lonic catheter inserted into the proximal colon. Co- the alterations of colonic transit immediately ob- lonic inflammation was induced by intracolonic ad- served after intracolonic