LIGNANS FROM THE AERIAL PARTS OF HAPLOPHYLLUM TUBERCULATUM…来自空气部分的木脂素.pdfVIP

Bull. Pharm. Sci., Assiut University, Vol. 28, Part 2, December 2005, pp. 261-267. LIGNANS FROM THE AERIAL PARTS OF HAPLOPHYLLUM TUBERCULATUM (FORSSK) A. JUSS D. T. A. Youssef Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt ﻲﻓ ﻮﻤﻨﻳىﺬﻟاﻢﺗﻼآﺮﺑﻮﻴﺗ ﻢﻠﻴﻓﻮﻠﺑﺎﻬﻟا تﺎﺒﻨﻟﺔﻴﺋاﻮﻬﻟا ءاﺰﺟﻸﻟﺔﻴﻟﻮﺤﻜﻟاﺔﺻﻼﺨﻟاﺔﻴﻘﻨﺗوﺔﺋﺰﺠﺗ تدأ .(2) لﻮﻨﻳﺰﻳﺮﻜﻳرﻻوﺰﻳاﻮﻜﻴﺳ (-)و(1) ﺎﻤهوتﺎﻧﺎﻨﺠﻠﻟاﻦﻣﻦﻴﺒآﺮﻣﻰﻠﻋفﺮﻌﺘﻟاوﻞﺼﻓﻰﻟاﺮﺼﻣ ﻰﻧﻮﺗوﺮﺒﻟا ﻰﺴﻴﻃﺎﻨﻐﻤﻟﺎىوﻮﻨﻟا ﻦﻴﻧﺮﻟاتﺎﺳاردماﺪﺨﺘﺳﺎﺑﺔﻟﻮﺼﻔﻤﻟا تﺎﺒآﺮﻤﻟاﻰﻠﻋ فﺮﻌﺘﻟا ﻢﺗ ﺪﻗو ﺪﺿﺔﻴﻟﺎﻌﻔﻟا ﺔﺳارد ﻢﺗ ﺪﻗو .ﺔﻠﺘﻜﻟافﺎﻴﻄﻣسﺎﻴﻗﻚﻟﺬآوﺎﻬﻋاﻮﻧﺎﺑتﺎﻴﺛاﺪﺣﻷاﻰﺋﺎﻨﺛوىدﺎﺣأﻰﻧﻮﺑﺮﻜﻟاو .تﺎﺒآﺮﻤﻟاﻩﺬﻬﻟﺔﻴﻧﺎﻃﺮﺴﻟاﺎﻳﻼﺨﻟا Bioassay-guided investigation of the aerial parts of Haplophyllum tuberculatum (Forssk) A. Juss grown in Egypt led to the isolation and characterization of two lignans, 1 and 2 [( −)- secoisolariciresinol]. The structural mapping of the isolated compounds was established on the basis of intensive 1D and 2D NMR studies. The anticancer activity of the isolated compounds was reported. INTRODUCTION EXPERIMENTAL The genus Haplophyllum (Rutaceae) General experimental procedures includes about 70 species spread out from the MPs were uncorrected. Optical rotations Mediterranean to Eastern Siberia.1 It is were measured on JASCO DIP-1000 digital represented in Egypt by three species namely, polarimeter. 1H and 13C NMR spectra were H. tuberculatum (Forssk) A. Juss, H. obovatum recorded on a Varian Unity 500 spectrometer at (Hochst. e