Lindane but not deltamethrin blocks a component of GABA…林丹，但不是溴氰菊酯阻断的一个组成部分.pdfVIP

Lindane but not deltamethrin blocks a component of GABA-activated chloride channels NOBUKUNI OGATA,*I STEPHEN M. VOGEL,1 AND TOSHIO NARAHASHI* *Departrnenl of Pharmacology, Northwestern University Medical Schoo4 Chicago, Illinois 60611, USA, tDepartmevt of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA, and 1Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka 812, Japan study with neuroblastoma cells has shown that lindane ABSTRACT has no effect on voltage-activated calcium channels (7). One of the possible sites of action of lindane is the ‘y- Effects of deltamethrin, a pyrethroid insecticide, and lin- aminobutyric acid (GABA)1 receptor-channel complex. dane, the gamma isomer of hexachlorocyclohexane, on The symptoms of poisoning clearly approximate those the ‘y-aminobutyric acid (GABA)-activated ion channels caused by convulsant GABA antagonists, and a chronic were studied using cultured neurons isolated from the exposure to a low dose of lindane produces proconvul- newborn rat dorsal root ganglia. The