Linehan et al Genetic basis of cancer of the ki基因癌症的基因基础.pdfVIP

6282s Vol. 10, 6282s–6289s, September 15, 2004 (Suppl.) Clinical Cancer Research Genetic Basis of Cancer of the Kidney: Disease-Specific Approaches to Therapy W. Marston Linehan,1 James Vasselli,1 mas, uterine leiomyomas (fibroids), and type 2 papillary Ramaprasad Srinivasan,1 McClellan M. Walther,1 RCC. The HLRC gene has been found to be the Krebs cycle Maria Merino,3 Peter Choyke,4 Cathy Vocke,1 enzyme, fumarate hydratase. Studies are under way to un- 6 1 derstand the downstream pathway of this cancer gene. Laura Schmidt, Jennifer S. Isaacs, Gladys Glenn,5 Jorge Toro,5 Berton Zbar,2 Donald Bottaro,1 and Len Neckers1 INTRODUCTION 1Urologic Oncology Branch, 2Laboratory of Immunobiology, Kidney cancer affects 32,000 people each year and is 3Laboratory of Pathology and 4Molecular Imaging Program, and responsible for nearly 12,000 deaths annually in the United 5Center for Cancer Research and Genetic Epidemiology Branch, States (1). Although there have been remarkable advances in the Division of Cancer Epidemiology and Genetics, National Cancer 6 development of immunologic forms of therapy for this disease, Institute, Bethesda, Maryland; and Basic Research Program, Science Applications International Corporation-Frederick, Inc., National currently there is still no effective form of therapy for most Cancer Institute Frederick, Fred