Localizing interference during naming Convergent neuroimaging…定位干扰期间的干扰收敛神经影像.pdfVIP

Localizing interference during naming: Convergent neuroimaging and neuropsychological evidence for the function of Broca’s area a,1 b c d c Tatiana T. Schnur , Myrna F. Schwartz , Daniel Y. Kimberg , Elizabeth Hirshorn , H. Branch Coslett , and Sharon L. Thompson-Schillc,e aDepartment of Psychology, Rice University, Houston, TX 77005; bMoss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Philadelphia, PA 19141; cDepartments of cNeurology and ePsychology, University of Pennsylvania, Philadelphia, PA 19104; and dDepartment of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627 Edited by Edward E. Smith, Columbia University, New York, NY, and approved November 19, 2008 (received for review June 18, 2008) To produce a word, the intended word must be selected from a production task that isolates competition during lexical selec- competing set of other words. In other domains where competition tion. In Exp. 1, we measured normal speakers’ brain activations affects the selection process, the left inferior frontal gyrus (LIFG) by using fMRI. In Exp. 2, we mapped performance deficits to responds to competition among incompatible representations. The lesion locations in participants with aphasia. aim of this study was to test whether the LIFG is necessary for Our approach has 3 major methodological strengths. First, we resolution of competition in word production. Using a method- used a well-studied speech production paradigm known to create ological approach applying the same rigorous analytic methods to competition during word selection (described in more detail neuropsychological data as is done with neuroimaging data, we b