临床研究和心力衰竭的治疗策略教材_课件.pptVIP

Eichhorn EJ, JCF. 2000;6(suppl 1):40-46. LVEF Time (months) Biologic Effect Pharmacologic Effect b-Blocker Initiated b-Blocker Discontinued 0 1 3 6 8 b受体阻滞剂对心衰患者射血分数的影响 Primary Outcomes of ? Blockers in Heart Failure p0.0001vs placebo p0.001vs placebo p=0.0062vs placebo p=0.00013vs placebo CIBIS-II Investigators and Committees. Lancet 1999;353:9-13; Colucci W S. Circulation 1996;94:2800-6 (U.S. Carvedilol) MERIT Study Group. Lancet 1999;253:2001-6; Packer M. Circulation 2002;106:2194-9 (COPERNICUS) Beta-blockers in HF carvedilol Metoprolol XL bisoprolol IA 所有慢性收缩性心衰， NYHAⅡ、Ⅲ级病情稳定患者，