Long Term Prognosis of Patients Diagnosed With Brugada…诊断为病人的长期预后.pdfVIP

Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome Results From the FINGER Brugada Syndrome Registry V. Probst, MD, PhD*; C. Veltmann, MD*; L. Eckardt, MD*; P.G. Meregalli, MD*; F. Gaita, MD; H.L. Tan, MD, PhD; D. Babuty, MD, PhD; F. Sacher, MD; C. Giustetto, MD; E. Schulze-Bahr, MD, PhD; M. Borggrefe, MD, PhD; M. Haissaguerre, MD; P. Mabo, MD, PhD; H. Le Marec, MD, PhD; C. Wolpert, MD, PhD; A.A.M. Wilde, MD, PhD Background—Brugada syndrome is characterized by ST-segment elevation in the right precordial leads and an increased risk of sudden cardiac death (SCD). Fundamental questions remain on the best strategy for assessing the real disease-associated arrhythmic risk, especially in asymptomatic patients. The aim of the present study was to evaluate the prognosis and risk factors of SCD in Brugada syndrome patients in the FINGER (France, Italy, Netherlands, Germany) Brugada syndrome registry. Methods and Results—Patients were recruited in 11 tertiary centers in 4 European countries. Inclusion criteria consisted of a type 1 ECG present either at baseline or after drug challenge, after exclusion of diseases that mimic Brugada syndrome. The registry included 1029 consecutive individuals (745 men; 72%) with a median age of 45 (35 to 55) years. Diagnosis was based on (1) aborted SCD (6%); (2) syncope, otherwise unexplained (30%); and (3) asymptomatic patients (64%). During a median follow-up of 31.9 (14 to 54.4) months, 51 cardiac events (5%) occurred (44 patients experienced appropriate implantable cardioverter-defibrillator shocks, and 7 died suddenly). The cardiac event rate per year was 7.7% in patients with aborted SCD, 1.9% in patients with syncope, and 0.5% in asymptom