Thalamic Volumes in Patients With First Episode Schizophrenia首发精神分裂症患者的丘脑体积.pdfVIP

Article Thalamic Volumes in Patients With First-Episode Schizophrenia Andrew R. Gilbert, M.D. Objective: The thalamus, a highly evolved Results: Right, left, and total thalamic vol- sensory and motor gateway to the cortex, umes of the patients with schizophrenia David R. Rosenberg, M.D. has been implicated in the pathophysiol- were significantly smaller than those of the ogy of several illnesses, including schizo- comparison subjects. Significantly smaller Keith Harenski, B.S. phrenia. Several studies have suggested volumes were found in the left central me- thalamic volume differences in patients dial subdivision of the patients as well as a with schizophrenia, although only a few Stephen Spencer, B.S. studies have examined thalamic structure smaller volume in the right central medial subdivision that approached significance. in new-onset patients. John A. Sweeney, Ph.D. Method: The authors used magnetic res- These regions primarily comprised the dorsomedial nucleus, a thalamic nucleus onance imaging to measure thalamic Matcheri S. Keshavan, M.D. volumes in previousl