The chelate effect in binding catalysis and chemotherapy结合催化和化疗的螯合作用.pdfVIP

Pure Appl. Chem., Vol. 72, No. 3, pp. 333–342, 2000. © 2000 IUPAC The chelate effect in binding, catalysis, and chemotherapy* † Ronald Breslow , Sandro Belvedere, Leland Gershell, and David Leung Department of Chemistry, Columbia University, New York, New York 10027, USA Abstract: Cyclodextrin (CD) dimers bind amino acid side chains, and such binding can dissociate aggregated proteins, including citrate synthase (dimer) and lactic dehy