The Association of OGG SerCys Polymorphism and Urinary …多态性与尿液相关性研究.pdfVIP

Karahalil B, et al. OGG1 GENE POLYMORPHISM AND 8-OHdG LEVELS IN LUNG CANCER PATIENTS 241 Arh Hig Rada Toksikol 2008;59:241-250 DOI: 10.2478/10004-1254-59-2008-1924 Scientific Paper THE ASSOCIATION OF OGG1 Ser326Cys POLYMORPHISM AND URINARY 8-OHdG LEVELS WITH LUNG CANCER SUSCEPTIBILITY: A HOSPITAL- BASED CASE-CONTROL STUDY IN TURKEY 1 1 2 2 3 z Bensu KARAHALIL , Esra EMERCE , Bülent KOÇER , Serdar HAN , Necati ALKIS , and Ali Esat KARAKAYA1 1 Gazi University, Faculty of Pharmacy, Department of Toxicology , Ankara Numune Education and Research Hospital, Department of Thoracic Surgery2, Ankara Oncology Education and Research Hospital, Department of Medical Oncology3, Ankara, Turkey Received in October 2008 Accepted in November 2008 High incidence and poor prognosis of lung cancer make it a major health problem worldwide. Although smoking is a major cause of lung cancer, only some smokers develop lung cancer, which suggests that there is a genetic predisposition in some individuals. 8-OHG is an important oxidative base lesion and may elevate due to cancer and smoking. It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has several polymorphisms. Although the Ser326Cys polymorphism is consistently associated with a range of cancers, findings