Prevention of gram-positive and Candida infections using精选.pdf

British Journal of Haematology, 1990, 76, Suppl. 2, 24-26 Prevention of Gram-positive and Candida albicans infections using teicoplanin and fluconazole: a randomized study in neutropenic children G.SCHAISON, A . BARUCHELAND G . ARLETSaint-Louis Hospital, Department of Pediatric Haematology, Paris, France Summary. We have shown that the combination of teicopla- B was used in febrile relapses. Forty-six patients were eligible nin (T) and ceftriaxone (C) given once daily as first-line (23 in each arm: no statistically significant differences empirical antimicrobial therapy is very effective (85%) and between the two groups). The mean age of the patients was 8 safe in febrile neutropenic children (ICAAC. 1988). Like years and mean duration of aplasia 2 3 and 2 4 d. Results were others (ICAAC. 1989) we have stressed the new Iife- as follows: arm A the duration of T + F alone was 10d, 22 threatening problems with Streptococcus rnitis and Strep. patients had a febrile episode with 1Gram-positive, 11 Gram- sunguis. Considering the regular sensitivity of Gram-positive negative and one candida strain isolated in eight patients. organisms to T. it is possible that the introduction of the C + A were effective in 72% of these patients. There were no glycopeptide at the onset of aplasia may be helpful. The high deaths. In arm B, fever occurred in all patients during the first incidence of fungal infection or superinfection supports the 6 d, with eight Gram-positive and six Gram-negative orga- routine use of an effective antifungal agent when fever is still nisms isolated in nine patients. present or relapse occurs. C+T+A were successful in 83% of patients. A bacterial Ou