心力衰竭管理发展历程精选.pptVIP

Gene Therapy Major challenges Development of an ideal vector (e.g. adenovirus) A method of delivery of these vectors Identification of appropriate gene targets, e.g. cardiac S100A1, a calcium binding gene, and sarcoplasmic reticular Ca2+ gene Mechanical assistance Cardiac transplantation will always be limited the availability of donor hearts Ventricular assist devices (VADs) Mainly used as bridges to transplantation As destination therapy? REMATCH trial: encouraging but the device was too large with many complications Ventricular assist devices (VADs) Current effort Reduce the incidence of