辛伐他汀对老年慢性阻塞性肺疾病患者血清IL.doc

辛伐他汀改善高龄慢性阻塞性肺疾病急性加重期患者肺功能的临床观察 刘 茜， 程 莉， 李 华， 甘 丹（400014 重庆，重庆市第三人民医院老年科） [摘要] 目的 探讨辛伐他汀对高龄慢性阻塞性肺疾病急性加重期（acute exacerbation chronic obstructive pulmonary disease, AECOPD）患者肺功能、全身及气道炎症反应的治疗效应。方法 将分为和对照组各例对照组给予在对照组基础上P ＜0.01Simvastatin improves lung functions of senile patients with acute exacerbation chronic obstructive pulmonary diseases Liu Xi, Cheng Li, Li Hua, Gan Dan (Department of Geriatrics, Third People’s Hospital of Chongqing, Chongqing, 400014, China) [Abstract] Objective To investigate the therapeutic effects of simvastatin on the pulmonary function, respiratory tract and systematic inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD) in elderly patients. Methods Eighty elderly patients suffering from AECOPD who hospitalized in our department from January 2009 to August 2012 were randomly and prospectively divided into experimental group (with an average age of 78.67?.25, n=40) and control group (with an average age of 83.25?.5, n=40)by. The control group was given conventional treatment for 2 weeks, meanwhile, the experimental group was added a simvastatin therapy (20 mg/d) beside the conventional treatment. ELIAS was performed to assess the level of IL-8 in the sputum and blood sputum obtained before and after the 2 weeks’ treatment. A pulmonary function detector was used to analyze the pulmonary function indices, such as FEV1, FEV1%, and FEV1/FVC at above time points. Results Only 70 patients finished our study, including 33 in experimental group and 37 in the control. Simvastatin therapy resulted in a significant improvement in the pulmonary function indices compared with those before treatment (P0.01), which were also obvious better than control group after 2 weeks’ treatment (P0.01). Simvastatin therapy also remarkably reduced the sputum and sputum levels of IL-8 than those before treatment (P0.01), and these level were also significantly lower than those in the control after treatment (P0.01). Conclusion Comb