原创力文档counter-ion complexes for enhanced drug loading in nanocarriers proof-of-concept and beyond：（抗衡离子复合物增强药物装载在人们概念验证）.pdfVIP
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counter-ion complexes for enhanced drug loading in nanocarriers proof-of-concept and beyond：（抗衡离子复合物增强药物装载在人们概念验证）
International Journal of Pharmaceutics 511 (2016) 994–1001
Contents lists available at ScienceDirect
International Journal of Pharmaceutics
journa l home page : www.e /locate/ijpharm
Counter-ion complexes for enhanced drug loading in nanocarriers:
Proof-of-concept and beyond
a,b a b,*
Nazende Günday Türeli , Akif E. Türeli , Marc Schneider
a MJR PharmJet GmbH, Industriestr. 1B, 66802 Überherrn, Germany
b Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbrücken, Germany
A R T I C L E I N F O A B S T R A C T
Article history:
Received 10 May 2016 Enhanced drug loading is an important prerequisite of nanomedicines, to reach administration dose
Received in revised form 2 August 2016 while reducing the amount of excipient. Considering biocompatible and biodegradable polymers such as
Accepted 3 August 2016 PLGA, pH dependent solubility characteristics along with limited organic solvent solubility of the drug
Available online 9 August 2016 hampers nanoparticle (NP) preparation. To improve loading of such molecules, a method based on using
counter ions for complex formation is proposed. Formed complex alters the intrinsic solubility of active
Chemical compounds studied in this article: substance via electrostatic interaction without chemical modification. A proof-of-concept study was
Acetonitrile (PubChem CID: 6342) condu
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