抗生素 (英文课件)ANTIBIOTICS.ppt

PHARMACOKINETICS Not absorbed can be given orally for intestinal candidiasis. Widely distributed with poor CSF penetration. Metabolized in liver with t1/2 of 15days excreted by urine bile. USES Gold standard of antifungal therapy. Used topically for oral, vaginal cutaneous candidiasis otomycosis Most effective for systemic mycoses. Reserve drug for resistant cases of kala azar. ADVERSE EFFECTS Acute reactions like chills, fever, aches,nausea, dyspnoea,etc. Thrombophlebitis of injected vein can occur. Nephrotoxicity is the most important long term effect. INTERACTIONS Flucyto